Article
Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.
Human genomics - 20 Jun 2015
Karageorgos Ioannis, Mizzi Clint, Giannopoulou Efstathia, Pavlidis Cristiana, Peters Brock A, Zagoriti Zoi, Stenson Peter D, Mitropoulos Konstantinos, Borg Joseph, Kalofonos Haralabos P, Drmanac Radoje, Stubbs Andrew, van der Spek Peter, Cooper David N, Katsila Theodora, Patrinos George P
Abstract excerpt
Cancer, like many common disorders, has a complex etiology, often with a strong genetic component and with multiple environmental factors contributing to susceptibility. A considerable number of genomic variants have been previously reported to be causative of, or associated with, an increased risk for various types of cancer. Here, we adopted a next-generation sequencing approach in 11 members of two families of...
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