Article

Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations

2020-01-13

Abstract excerpt

It is estimated that up to 10% of cancer incidents are attributed to inherited genetic alterations. Despite extensive research, there are still gaps in our understanding of genetic predisposition to cancer. It was theorized that ultra-rare variants partially account for the missing heritable component. We harness the UK BioBank dataset of ∼500,000 individuals, 14% of which were diagnosed with cancer, to detect ult...

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Literature Corpus work: 6f31eba4-f9b7-5216-b46c-6a7013e55443
DOI: 10.1101/2020.01.09.19015867

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