Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.

Human molecular genetics - 1 Sept 2015

Sun Xinliang, Chen Hongbo, Deng Zaian, Hu Bo, Luo Hui, Zeng Xiaobin, Han Liqiao, Cai Guoping, Ma Lan

Abstract excerpt

DDX11 was recently identified as a cause of Warsaw breakage syndrome (WABS). However, the functional mechanism of DDX11 and the contribution of clinically described mutations to the pathogenesis of WABS are elusive. Here, we show that DDX11 is a novel nucleolar protein that preferentially binds to hypomethylated active ribosomal DNA (rDNA) gene loci, where it interacts with upstream binding factor (UBF) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleolus
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Embryonic Development

Share to Gene Knockdown Techniques

Share to RNA, Ribosomal

Share to RNA, Small Interfering

Share to Zebrafish

Source

Identifiers

PMID: 26089203
DOI: 10.1093/hmg/ddv213

Genes

DDX11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.PMID 26089203Read ↗

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology.Semantic proximity Read ↗

Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome.Semantic proximity Read ↗

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of gliomaSemantic proximity Read ↗

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.Semantic proximity Read ↗

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processesSemantic proximity Read ↗

The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.Semantic proximity Read ↗

The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translationSemantic proximity Read ↗

The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.Semantic proximity Read ↗

The Wnt/β-Catenin Pathway is Activated as a Novel Nucleolar Stress Response.Semantic proximity Read ↗

FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination.Semantic proximity Read ↗

Protein UFMylation regulates early events of ribosomal DNA double-stranded break responseSemantic proximity Read ↗

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.