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Article

Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.

Cancer genetics - 1 Jan 2000

Boora Ganesh K, Kanwar Rahul, Kulkarni Amit A, Pleticha Josef, Ames Matthew, Schroth Gary, Beutler Andreas S, Banck Michaela S

Abstract excerpt

Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumors (NET) and have been instrumental in the design of clinical trials targeting the PI3K/AKT/mTOR pathways, VEGF inhibitors, and somatostatin analogues. It remains unknown, however, whether the genomic makeup of NET cell lines reflect that of primary NET since comprehensive unbiased genome sequencing has not been...

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Source

Identifiers

PMID: 26087898
DOI: 10.1016/j.cancergen.2015.04.002

Genes

ATRX
DAXX
MEN1
APC
BRCA1
GNAS
KDR
NOTCH1
STK11
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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