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Article

Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3.

Human pathology - 1 Jul 2018

Konukiewitz Björn, Jesinghaus Moritz, Steiger Katja, Schlitter Anna Melissa, Kasajima Atsuko, Sipos Bence, Zamboni Giuseppe, Weichert Wilko, Pfarr Nicole, Klöppel Günter

Abstract excerpt

Pancreatic neuroendocrine carcinoma is a rare aggressive tumor commonly harboring TP53 and RB1 alterations and lacking neuroendocrine-related genetic changes such as mutations in MEN1 and ATRX/DAXX. Little is known about its genetic profile with regard to that of pancreatic ductal adenocarcinoma. We therefore conducted a detailed genetic study in 12 pancreatic neuroendocrine carcinomas of large cell (n = 9) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Pancreatic Ductal

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Source

Identifiers

PMID: 29596894
DOI: 10.1016/j.humpath.2018.03.018

Genes

KRAS
APC
ATRX
DAXX
MEN1
MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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