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Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation

9 Sept 2010

Abstract excerpt

The transcription factor p63 is required for proper epidermal barrier formation and maintenance. Herein, we used chromatin immunoprecipitation coupled with DNA sequencing to identify novel p63 target genes involved in normal human epidermal keratinocyte (NHEKs) growth and differentiation. We identified over 2000 genomic sites bound by p63, of which 82 were also transcriptionally regulated by p63 in NHEKs. Through...

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PMID: 21151771
DOI: 10.1038/cddis.2010.49

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