Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes

7 Jun 2012

Abstract excerpt

The interfollicular epidermis is continuously renewed, thanks to a regulated balance between proliferation and differentiation. The ΔNp63 transcription factor has a key role in the control of this process. It has been shown that ΔNp63 directly regulates Runt-related transcription factor 1 (RUNX1) transcription factor expression in mouse keratinocytes. The present study showed for the first time that RUNX1 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer and Skin Lesions
Share to Cancer-related Molecular Pathways
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22673192
DOI: 10.1038/cddis.2012.62

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytesPMID 22673192Read ↗

Intersection of the p63 and NF‐κB pathways in epithelial homeostasis and diseaseSemantic proximity Read ↗

p63: Defining roles in morphogenesis, homeostasis, and neoplasia of the epidermisSemantic proximity Read ↗

Distinct interactors define the p63 transcriptional signature in epithelial development or cancerSemantic proximity Read ↗

An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.Semantic proximity Read ↗

Master regulatory role of p63 in epidermal development and disease.Semantic proximity Read ↗

Induced multipotency in adult keratinocytes through down-regulation of <i>ΔNp63</i> or <i>DGCR8</i>Semantic proximity Read ↗

Transcriptional Network of p63 in Human KeratinocytesSemantic proximity Read ↗

DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes.Semantic proximity Read ↗

The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes.Semantic proximity Read ↗

ΔNp63α Repression of the <i>Notch1</i> Gene Supports the Proliferative Capacity of Normal Human Keratinocytes and Cervical Cancer CellsSemantic proximity Read ↗

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.Semantic proximity Read ↗

MicroRNAs and p63 in epithelial stemnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.