Article
COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2015
Fang Jingye, Liu Ming, Zhang Xuebao, Sakamoto Takeshi, Taatjes Douglas J, Jena Bhanu P, Sun Fei, Woods James, Bryson Tim, Kowluru Anjaneyulu, Zhang Kezhong, Chen Xuequn
Abstract excerpt
Pancreatic β-cells possess a highly active protein synthetic and export machinery in the endoplasmic reticulum (ER) to accommodate the massive production of proinsulin. ER homeostasis is vital for β-cell functions and is maintained by the delicate balance between protein synthesis, folding, export, and degradation. Disruption of ER homeostasis by diabetes-causing factors leads to β-cell death. Among the 4...
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