Differential effects of a GTP-restricted mutant of Sar1p on segregation of cargo during export from the endoplasmic reticulum.

Abstract excerpt

Export of cargo from the endoplasmic reticulum (ER) is the first membrane trafficking step in the secretory pathway. To date, all cargo proteins appear to use a common set of machinery for the initial stages of export, namely the COPII coat complex. Recent data from both yeast and mammalian systems have emerged suggesting that specific cargoes could be sorted from one another at the point of exit from the...

Topics

• Endoplasmic Reticulum
• Guanosine Triphosphate
• HeLa Cells
• Humans
• Microscopy, Confocal
• Monomeric GTP-Binding Proteins
• Mutation
• Protein Transport