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Article

Allele-specific real-time PCR system for detection of subpopulations of genotype 1a and 1b hepatitis C NS5B Y448H mutant viruses in clinical samples.

Journal of clinical microbiology - 1 Sept 2011

Bae Andrew S, Ku Karin S, Miller Michael D, Mo Hongmei, Svarovskaia Evguenia S

Abstract excerpt

The Y448H mutation in NS5B has been selected by GS-9190 as well as several benzothiadiazine hepatitis C virus (HCV) polymerase inhibitors in vitro and in vivo. However, the level and the evolution kinetics of this resistance mutation prior to and during treatment are poorly understood. In this study, we developed an allele-specific real-time PCR (AS-PCR) assay capable of detecting Y448H when it was present at a...

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Source

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Identifiers

PMID: 21715590
DOI: 10.1128/JCM.00274-11
PMCID: PMC3165570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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