Article
Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.
Journal of gastroenterology - 1 Mar 2016
Uchida Yoshihito, Kouyama Jun-Ichi, Naiki Kayoko, Sugawara Kayoko, Ando Satsuki, Nakao Masamitsu, Motoya Daisuke, Inao Mie, Imai Yukinori, Nakayama Nobuaki, Mochida Satoshi
Abstract excerpt
BACKGROUND: Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS: The percent of serum NS5A-Y93H strains relative to the total strains was quantified using cycling-probe real-time PCR combined with direct...
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