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Article

Controversies in Intrapatient Melanoma BRAFV600E Mutation Status.

The American Journal of dermatopathology - 1 Apr 2017

Riveiro-Falkenbach Erica, Santos-Briz Angel, Ríos-Martín Juan J, Rodríguez-Peralto José L

Abstract excerpt

Therapies targeting the BRAF oncogene have improved the overall and disease-free survival of patients with advanced melanomas. An unresolved issue in clinical practice is the existence (or not) of BRAF-mutated and BRAF-nonmutated tumors in individual patients (intrapatient BRAF mutation heterogeneity), which may serve as a mechanism of resistance to BRAF inhibitors or lead to diagnostic problems. Different...

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Identifiers

PMID: 28323782
DOI: 10.1097/DAD.0000000000000710

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BRAF

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