Article
BRAFV600E protein expression in primary cutaneous malignant melanomas and paired metastases.
JAMA dermatology - 1 Apr 2015
Eriksson Hanna, Zebary Abdlsattar, Vassilaki Ismini, Omholt Katarina, Ghaderi Mehran, Hansson Johan
Abstract excerpt
IMPORTANCE: BRAFV600E mutations are present in approximately 50% of cutaneous malignant melanomas (CMMs). The use of BRAFV600E mutation-specific monoclonal antibody VE1 immunohistochemical analysis may facilitate rapid detection of BRAFV600E mutations in CMMs and demonstrate heterogeneity among tumors. OBJECTIVES: To characterize the pattern of BRAFV600E protein expression in primary CMMs with matched metastases...
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