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Article

Utility of BRAF V600E Immunohistochemistry Expression Pattern as a Surrogate of BRAF Mutation Status in 154 Patients with Advanced Melanoma.

Human pathology - 1 Aug 2015

Tetzlaff Michael T, Pattanaprichakul Penvadee, Wargo Jennifer, Fox Patricia S, Patel Keyur P, Estrella Jeannelyn S, Broaddus Russell R, Williams Michelle D, Davies Michael A, Routbort Mark J, Lazar Alexander J, Woodman Scott E, Hwu Wen-Jen, Gershenwald Jeffrey E, Prieto Victor G, Torres-Cabala Carlos A, Curry Jonathan L

Abstract excerpt

Successful BRAF inhibitor therapy depends on the accurate assessment of the mutation status of the BRAF V600 residue in tissue samples. In melanoma, immunohistochemical (IHC) analysis with monoclonal anti-BRAF V600E has emerged as a sensitive and specific surrogate of BRAF V600E mutation, particularly when BRAF V600E protein expression is homogeneous and strong. A subset of melanomas exhibit heterogeneous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26058727
DOI: 10.1016/j.humpath.2015.04.012
PMCID: PMC4515190

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Utility of BRAF V600E Immunohistochemistry Expression Pattern as a Surrogate of BRAF Mutation Status in 154 Patients with Advanced Melanoma.PMID 26058727Read ↗

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Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.Semantic proximity Read ↗

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