Article
BRAFV600E Expression Is Homogenous and Associated with Nonrecurrent Disease and Better Survival in Primary Melanoma.
Dermatology (Basel, Switzerland) - 1 Jan 2023
Naimy Soraya, Bzorek Michael, Eriksen Jens Ole, Dyring-Andersen Beatrice, Rahbek Gjerdrum Lise Mette
Abstract excerpt
BACKGROUND: Superficial spreading melanomas (SSMs) are the most common type of melanoma and cause the majority of skin cancer deaths. More than 50% of cases harbor a mutation in the BRAF gene that activates the mitogen-activated protein kinase (MAPK) cancer signaling pathway. BRAFV600E is the most common BRAF mutation, and it represents an important biomarker that guides treatment selection. However, the...
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