Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAFV600E immunopositive melanomas show low frequency of heterogeneity and association with epithelioid tumor cells: a STROBE-compliant article.

Medicine - 1 Dec 2014

Verlinden Ivana, van den Hurk Karin, Clarijs Ruud, Willig Arjan P, Stallinga Cecile M H A, Roemen Guido M J M, van den Oord Joost J, Zur Hausen Axel, Speel Ernst-Jan M, Winnepenninckx Véronique J L

Abstract excerpt

Treatment of BRAFV600E-mutant melanoma by small molecule inhibitors that target BRAFV600E or MEK kinases is increasingly used in clinical practice and significantly improve patient outcome. However, patients eventually become resistant and therapeutic improvement is required. Molecular diversity within individual tumors (intratumor heterogeneity) and between tumors within a single patient (intrapatient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Immunohistochemistry

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25526463
DOI: 10.1097/MD.0000000000000285
PMCID: PMC4603111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAFV600E immunopositive melanomas show low frequency of heterogeneity and association with epithelioid tumor cells: a STROBE-compliant article.PMID 25526463Read ↗

BRAF Immunoexpression Can Be Intralesionally Heterogeneous but BRAF V600E Mutation Status Is Intralesionally Homogeneous and Interlesionally Concordant in Melanoma: A Study of 140 Lesions From 98 Patients.Semantic proximity Read ↗

BRAF Heterogeneity in Melanoma.Semantic proximity Read ↗

Heterogeneity in MelanomaSemantic proximity Read ↗

Intratumor and Intertumor Heterogeneity in MelanomaSemantic proximity Read ↗

Intrapatient homogeneity of BRAFV600E expression in melanoma.Semantic proximity Read ↗

Controversies in Intrapatient Melanoma BRAFV600E Mutation Status.Semantic proximity Read ↗

Utility of BRAF V600E Immunohistochemistry Expression Pattern as a Surrogate of BRAF Mutation Status in 154 Patients with Advanced Melanoma.Semantic proximity Read ↗

Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.Semantic proximity Read ↗

Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine.Semantic proximity Read ↗

Intra- and Inter-Tumoral Homogeneity of BRAF(V600E) Mutations in Melanoma Tumors.Semantic proximity Read ↗

Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma PatientsSemantic proximity Read ↗

BRAFV600E Expression Is Homogenous and Associated with Nonrecurrent Disease and Better Survival in Primary Melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.