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Article

Naturally occurring resistance mutations to HIV-1 entry inhibitors in subtypes B, C, and CRF31_BC.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2012

Araújo Leonardo Augusto Luvison, Junqueira Dennis Maletich, de Medeiros Rubia Marília, Matte Maria Cristina Cotta, Almeida Sabrina Esteves de Matos

Abstract excerpt

BACKGROUND: Entry inhibitors are a class of antiretroviral (ARV) drugs that prevent HIV replication by blocking viral entry into the host cell. The investigation of naturally occurring mutations associated with entry inhibitors across subtypes is required because genetic differences between HIV-1 variants may influence the emergence of drug resistance. Despite the importance of subtype C, which predominates...

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PMID: 22336085
DOI: 10.1016/j.jcv.2012.01.005

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