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Article

Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B.

Virologica Sinica - 1 Apr 2020

Wang Zheng, Ji Xiaolin, Hao Yanling, Hong Kunxue, Ma Liying, Li Dan, Shao Yiming

Abstract excerpt

HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation, stabilization, and translation of the viral mRNAs. Rev of HIV-1 clade BC often shows a truncation of 16 AAs due to a premature stop codon at residue 101. This stop codon presents the highest frequency in clade BC and the lowest frequency in clade B. In order to discover the potential biological effect of this truncation on Rev...

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Identifiers

PMID: 31828587
DOI: 10.1007/s12250-019-00179-0
PMCID: PMC7198662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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