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Article

Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.

Journal of endodontics - 1 Aug 2015

Applebaum Elizabeth, Nackley Andrea G, Bair Eric, Maixner William, Khan Asma A

Abstract excerpt

INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) have a well-established analgesic efficacy for inflammatory pain. These drugs exert their effect by inhibiting the enzyme cyclooxygenase (COX) and are commonly used for the management of pain after endodontic treatment. There are 2 distinct isoforms of COX: COX-1, which is constitutively expressed, and COX-2, which is primarily induced by inflammation....

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Identifiers

PMID: 26081267
DOI: 10.1016/j.joen.2015.04.021
PMCID: PMC4519379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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