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Article

Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw.

Clinical pharmacology and therapeutics - 1 Dec 2021

Yang Guang, Singh Sonal, McDonough Caitrin W, Lamba Jatinder K, Hamadeh Issam, Holliday L Shannon, Wang Danxin, Katz Joseph, Lakatos Peter A, Balla Bernadett, Kosa Janos P, Pelliccioni Gian Andrea, Price Douglas K, Van Driest Sara L, Figg William D, Langaee Taimour, Moreb Jan S, Gong Yan

Abstract excerpt

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious drug-related adverse event. To identify pharmacogenomic markers of MRONJ associated with bisphosphonate therapy, we conducted a genomewide association study (GWAS) meta-analysis followed by functional analysis of 5,008 individuals of European ancestry treated with bisphosphonates, which includes the largest number of MRONJ cases to date...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34390503
DOI: 10.1002/cpt.2397
PMCID: PMC8630710

Genes

FDFT1
BLK
CTSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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