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Association of Single Nucleotide Polymorphisms in the Cyclooxygenase-2 (COX-2) Gene with Periodontal Disease: A Systematic Review with Meta-Analysis and Implications for Personalized Dentistry

2025-06-26

Abstract excerpt

<h4>Background: </h4> Periodontitis is a multifactorial inflammatory disease with complex interactions between microbial, environmental, and genetic factors. Cyclooxygenase-2 (COX-2), a key enzyme in prostaglandin synthesis, plays a significant role in periodontal inflammation. Single nucleotide polymorphisms (SNPs) in the COX-2 gene—particularly -765G/C (rs20417) and -1195G/A (rs689466)—have been investigated for...

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Literature Corpus work
c40c61bd-fd84-5d7c-93f9-e413a97f1ee1
DOI
10.20944/preprints202506.2187.v1
Open publication

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Association of Single Nucleotide Polymorphisms in the Cyclooxygenase-2 (COX-2) Gene with Periodontal Disease: A Systematic Review with Meta-Analysis and Implications for Personalized DentistryDOI 10.20944/preprints202506.2187.v1
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