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Article

Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma.

Cancer science - 1 Sept 2015

Mori Takahiro, Sumii Makiko, Fujishima Fumiyoshi, Ueno Kazuko, Emi Mitsuru, Nagasaki Masao, Ishioka Chikashi, Chiba Natsuko

Abstract excerpt

BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that is involved in the regulation of cell growth. Recently, many somatic and germline mutations of BAP1 have been reported in a broad spectrum of tumors. In this study, we identified a novel somatic non-synonymous BAP1 mutation, a phenylalanine-to-isoleucine substitution at codon 170 (F170I), in 1 of 49 patients with esophageal squamous cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26081045
DOI: 10.1111/cas.12722
PMCID: PMC4582980

Genes

BAP1
BRCA1
TCEAL7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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