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Article

A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells.

International journal of biological macromolecules - 1 Jun 2021

Ma Ying, Weng Jun, Wang Ning, Zhang Yilei, Minato Nagahiro, Su Li

Abstract excerpt

Signal-induced proliferation-associated protein 1 (SIPA1) is highly expressed and mainly located in the nucleus in some breast cancer cell lines and clinical tumor tissues. Previous study revealed that nuclear localization of SIPA1 is functionally involved in breast cancer metastasis in the lymphatic gland. In the current study, we identified a non-typical region (140-179aa) of SIPA1 as a novel nuclear...

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PMID: 33753200
DOI: 10.1016/j.ijbiomac.2021.03.101

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