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Article

Frequent epigenetic inactivation of <i>hSRBC</i> in gastric cancer and its implication in attenuated p53 response to stresses

4 Dec 2007

Abstract excerpt

hSRBC is a putative tumor suppressor located at 11p15.4, at which frequent genomic loss has been observed in several human malignancies. To explore the candidacy of hSRBC as a suppressor of gastric tumorigenesis, we analyzed the expression and mutation status of hSRBC in gastric tissues and cell lines. hSRBC transcript was expressed in all normal and benign tumor tissues examined, but undetectable or very low in...

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PMID: 18059034
DOI: 10.1002/ijc.23166

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