Article
Sub-optimal phenotypes of double-knockout mutants of Escherichia coli depend on the order of gene deletions.
Integrative biology : quantitative biosciences from nano to macro - 1 Aug 2015
Gawand Pratish, Said Abukar Fatumina, Venayak Naveen, Partow Siavash, Motter Adilson E, Mahadevan Radhakrishnan
Abstract excerpt
Metabolic networks are characterized by multiple redundant reactions that do not have a clear biological function. The redundancies in the metabolic networks are implicated in adaptation to random mutations and survival under different environmental conditions. Reactions that are not active under wild-type growth conditions, but get transiently activated after a mutation event such as gene deletion are known as...
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