Article

A novel S1PR4 functional antagonist prevents nonalcoholic steatohepatitis by deactivating the NLRP3 inflammasome without causing lymphopenia

2020-11-13

Abstract excerpt

<title>Abstract</title> <p>Sphingosine 1-phosphate (S1P) receptors (S1PRs) are a group of G protein-coupled receptors that confer a broad range of functional effects in chronic inflammatory diseases and metabolic diseases. S1PRs may also be involved in the development of non-alcoholic steatohepatitis (NASH), but the specific subtypes involved and the mechanism of action are unclear. Here we show that the livers o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f7b33bb-3f34-50ca-b228-514c04bc34c9
DOI: 10.21203/rs.3.rs-96492/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel S1PR4 functional antagonist prevents nonalcoholic steatohepatitis by deactivating the NLRP3 inflammasome without causing lymphopeniaDOI 10.21203/rs.3.rs-96492/v1Read

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steato-sis and InflammationSemantic proximity Read

Tirzepatide but not Semaglutide Ameliorates Hepatic Steatosis and Inflammatory Infiltration in a Mouse Model of MASLD via Inhibition of the CCL2/CCR2-PI3K-Akt PathwaySemantic proximity Read

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver diseaseSemantic proximity Read

Efficacy and Safety of GLP-1 Receptor Agonists in Patients with MASLD: A Systematic Review and Meta-analysis of Randomized Clinical TrialsSemantic proximity Read

Osteoprotegerin deficiency aggravates methionine- choline- deficient diet-induced nonalcoholic steatohepatitis in miceSemantic proximity Read

TLR4 promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis by a mechanism independent of hepatocytes and inflammatory cellsSemantic proximity Read

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacologySemantic proximity Read

PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolic Dysfunction–Associated Steatotic Liver DiseaseSemantic proximity Read

Lysophospholipid G protein-coupled receptors.Semantic proximity Read

Palmitate-Induced S1P Signaling Pathway Attenuates by Cchicoric Acid in Human Peripheral Blood Mononuclear CellsSemantic proximity Read

S1pr1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lungSemantic proximity Read

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and PolarizationSemantic proximity Read