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Article

Specific stabilization of CFTR by phosphatidylserine.

Biochimica et biophysica acta. Biomembranes - 1 Feb 2017

Hildebrandt Ellen, Khazanov Netaly, Kappes John C, Dai Qun, Senderowitz Hanoch, Urbatsch Ina L

Abstract excerpt

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) is a plasma membrane chloride ion channel in the ABC transporter superfamily. CFTR is a key target for cystic fibrosis drug development, and its structural elucidation would advance those efforts. However, the limited in vivo and in vitro stability of the protein, particularly its nucleotide binding domains, has made structural studies...

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Source

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Identifiers

PMID: 27913277
DOI: 10.1016/j.bbamem.2016.11.013
PMCID: PMC5237360

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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