Article
Specific stabilization of CFTR by phosphatidylserine.
Biochimica et biophysica acta. Biomembranes - 1 Feb 2017
Hildebrandt Ellen, Khazanov Netaly, Kappes John C, Dai Qun, Senderowitz Hanoch, Urbatsch Ina L
Abstract excerpt
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) is a plasma membrane chloride ion channel in the ABC transporter superfamily. CFTR is a key target for cystic fibrosis drug development, and its structural elucidation would advance those efforts. However, the limited in vivo and in vitro stability of the protein, particularly its nucleotide binding domains, has made structural studies...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Binding Sites
- Cell Line
- Cell Membrane
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- Hydrolysis
- Mutation
- Nucleotides
- Phosphatidylserines
- Protein Binding