Protein-only mechanism induces self-perpetuating changes in the activity of neuronal <i>Aplysia</i> cytoplasmic polyadenylation element binding protein (CPEB)

Abstract excerpt

Neuronal cytoplasmic polyadenylation element binding protein (CPEB) plays a critical role in maintaining the functional and morphological long-lasting synaptic changes that underlie learning and memory. It can undergo a prion switch, but it remains unclear if this self-templating change in protein conformation is alone sufficient to create a stable change in CPEB activity: a robust "protein-only" biochemical...

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