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Article

Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach.

Cancer research - 1 Aug 2015

Cerasuolo Marianna, Paris Debora, Iannotti Fabio A, Melck Dominique, Verde Roberta, Mazzarella Enrico, Motta Andrea, Ligresti Alessia

Abstract excerpt

Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisition may involve neuroendocrine transdifferentiation, but there is little knowledge about this...

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PMID: 26069250
DOI: 10.1158/0008-5472.CAN-14-3830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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