Article
Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells.
The Prostate - 1 Jan 2009
Mori Ryutaro, Xiong Shigang, Wang Qingcai, Tarabolous Chad, Shimada Hiroshi, Panteris Eleftherios, Danenberg Kathleen D, Danenberg Peter V, Pinski Jacek K
Abstract excerpt
BACKGROUND: Neuroendocrine (NE) cells are present in both normal prostate and prostate cancer. In addition, NE differentiation can be induced by various factors, such as IL-6, in vitro and in vivo. However, the mechanism of this differentiation and the role of NE cells in prostate cancer are not well understood. In this study, we evaluated the gene expression and analyzed the pathways in prostate cancer cells...
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