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Article

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Biochemistry - 11 Jul 2017

Chen Jonathan L, VanEtten Damian M, Fountain Matthew A, Yildirim Ilyas, Disney Matthew D

Abstract excerpt

RNA repeat expansions cause a host of incurable, genetically defined diseases. The most common class of RNA repeats consists of trinucleotide repeats. These long, repeating transcripts fold into hairpins containing 1 × 1 internal loops that can mediate disease via a variety of mechanism(s) in which RNA is the central player. Two of these disorders are Huntington's disease and myotonic dystrophy type 1, which are...

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Identifiers

PMID: 28617590
DOI: 10.1021/acs.biochem.7b00252
PMCID: PMC5810133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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