Article
Schizophrenia-Like Phenotype Inherited by the F2 Generation of a Gestational Disruption Model of Schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2016
Perez Stephanie M, Aguilar David D, Neary Jennifer L, Carless Melanie A, Giuffrida Andrea, Lodge Daniel J
Abstract excerpt
Both environmental and genetic factors contribute to schizophrenia; however, the exact etiology of this disorder is not known. Animal models are utilized to better understand the mechanisms associated with neuropsychiatric diseases, including schizophrenia. One of these involves gestational administration of methylazoxymethanol acetate (MAM) to induce a developmental disruption, which in turn produces a...
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