Article
Prenatal nutritional deficiency reprogrammed postnatal gene expression in mammal brains: implications for schizophrenia.
The international journal of neuropsychopharmacology - 31 Oct 2014
Xu Jiawei, He Guang, Zhu Jingde, Zhou Xinyao, St Clair David, Wang Teng, Xiang Yuqian, Zhao Qingzhu, Xing Qinghe, Liu Yun, Wang Lei, Li Qiaoli, He Lin, Zhao Xinzhi
Abstract excerpt
BACKGROUND: Epidemiological studies have identified prenatal exposure to famine as a risk factor for schizophrenia, and animal models of prenatal malnutrition display structural and functional brain abnormalities implicated in schizophrenia. METHODS: The offspring of the RLP50 rat, a recently developed animal model of prenatal famine malnutrition exposure, was used to investigate the changes of gene expression...
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