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Article

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.

Journal of structural biology - 1 Aug 2015

Škerlová Jana, Král Vlastimil, Kachala Michael, Fábry Milan, Bumba Ladislav, Svergun Dmitri I, Tošner Zdeněk, Veverka Václav, Řezáčová Pavlína

Abstract excerpt

The hyaluronate receptor CD44 plays role in cell adhesion and migration and is involved in tumor metastasis. The extracellular domain of CD44 comprises the hyaluronate-binding domain (HABD) and the membrane-proximal stem region; the short intracellular portion interacts with adaptor proteins and triggers signaling pathways. Binding of hyaluronate to CD44 HABD induces an allosteric conformational change, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26066970
DOI: 10.1016/j.jsb.2015.06.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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