Article
Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells.
PloS one - 1 Jan 2012
Masuko Kazue, Okazaki Shogo, Satoh Mayumi, Tanaka Goh, Ikeda Tatsuya, Torii Ryota, Ueda Eri, Nakano Takashi, Danbayashi Masaaki, Tsuruoka Tomoyo, Ohno Yoshiya, Yagi Hideki, Yabe Noritsugu, Yoshida Hideaki, Tahara Tomoyuki, Kataoka Shiro, Oshino Taichi, Shindo Takayuki, Niwa Shin-ichiro, Ishimoto Takatsugu, Baba Hideo, Hashimoto Yoshiyuki, Saya Hideyuki, Masuko Takashi
Abstract excerpt
BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. The stem structure of CD44 encoded by ten normal exons can be enlarged by ten variant exons (v1-v10) by alternative splicing. We have succeeded in preparing MV5 fully human IgM and its class-switched GV5 IgG monoclonal antibody (mAb) recognizing the extracellular domain of a CD44R1 isoform that contains the inserted region coded by variant (v8,...
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