The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events

Abstract excerpt

CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major hyaluronan receptor on most cell types. Although alternative splicing can produce a large number of different isoforms, they all retain the hyaluronan-binding Link-homology region and a common transmembrane and cytoplasmic domain, which are highly conserved between species. The past decade has seen an extensive investigation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Adhesion Molecules Research
• Share to Glycosylation and Glycoproteins Research
• Share to Proteoglycans and glycosaminoglycans research