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Article

Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.

The Journal of biological chemistry - 28 Sept 2012

Ma Jichun, Tang Wai Kwan, Esser Lothar, Pastan Ira, Xia Di

Abstract excerpt

Mesothelin is a tumor differentiation antigen that is highly expressed in many epithelial cancers, with limited expression in normal human tissues. Binding of mesothelin on normal mesothelial cells lining the pleura or peritoneum to the tumor-associated cancer antigen 125 (CA-125) can lead to het...

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Identifiers

PMID: 22787150
DOI: 10.1074/jbc.M112.381756
PMCID: PMC3460419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22787150-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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