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Article

Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jun 2008

Toole Bryan P, Slomiany Mark G

Abstract excerpt

Hyaluronan not only is an important structural component of extracellular matrices but also interacts with cells during dynamic cell processes such as those occurring in cancer. Consequently, interactions of hyaluronan with tumor cells play important cooperative roles in various aspects of malignancy. Hyaluronan binds to several cell surface receptors, including CD44, thus leading to co-regulation of signaling...

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Identifiers

PMID: 18490190
DOI: 10.1016/j.drup.2008.04.002
PMCID: PMC2584579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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