Article

Immunoreactivity of Humanized Single-Chain Variable Fragment Against Its Functional Epitope On Domain 1 of CD147

2021-10-19

Abstract excerpt

Domain 1 of CD147 participates in matrix metalloproteinase (MMP) production and is a candidate for targeted therapy to prevent cancer invasion and metastasis. A functional mouse anti-CD147 monoclonal antibody, M6-1B9, was found to recognize domain 1 of CD147, and its respective mouse single-chain variable fragment (ScFvM61B9) was subsequently generated. The EDLGS epitope candidate for M6-1B9 was identified using t...

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Literature Corpus work: 9c4bdc37-4653-50f9-b7b8-ce4537cbfeff
DOI: 10.21203/rs.3.rs-964906/v1

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