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Article

The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development.

Development (Cambridge, England) - 1 Nov 2013

Miri Kamelia, Latham Keith, Panning Barbara, Zhong Zhisheng, Andersen Angela, Varmuza Susannah

Abstract excerpt

Imprinted genes play important roles in placenta development and function. Parthenogenetic embryos, deficient in paternally expressed imprinted genes, lack extra-embryonic tissues of the trophoblast lineage. Parthenogenetic trophoblast stem cells (TSCs) are extremely difficult to derive, suggesting that an imprinted gene(s) is necessary for TSC establishment or maintenance. In a candidate study, we were able to...

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Source

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Identifiers

PMID: 24154523
DOI: 10.1242/dev.096511
PMCID: PMC3817938

Genes

SFMBT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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