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Article

The roles of mutant p53 in reprogramming and inflammation in breast cancers.

Cell death and differentiation - 1 Nov 2025

Kummar Shivaani, Fellous Marc, Levine Arnold J

Abstract excerpt

Rezatapopt is an investigational small molecule p53 reactivator that binds specifically to the Y220C-mutant p53 protein without interacting with wild-type or other mutant p53 proteins. Upon binding, rezatapopt stabilizes the Y220C-mutant p53 protein in the wild-type conformation, reactivating p53 functions. The Phase 1 PYNNACLE trial assessed rezatapopt in solid tumors. One study participant with triple-negative...

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Identifiers

PMID: 40696138
DOI: 10.1038/s41418-025-01549-w
PMCID: PMC12572242

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The roles of mutant p53 in reprogramming and inflammation in breast cancers.PMID 40696138Read ↗

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Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule ReactivatorSemantic proximity Read ↗

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