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Interleukin-10 overexpression in 4T1 cells: A gateway to suppressing mammary carcinoma growth

7 Sept 2024

Abstract excerpt

• IL-10 overexpression in TNBC suppresses tumor growth by increasing IFN-γ secreting CD8 + T cells and decreasing MDSCs in the tumor microenvironment. • Tumor-derived IL-10 reduces MDSCs infiltration through inhibition of myeloid cell differentiation and CXCL5 downregulation. • CXCL5 expression and MDSC infiltration correlate in human breast cancer, suggesting targeting the IL-10-CXCL5-MDSCs axis for...

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PMID: 39244897
DOI: 10.1016/j.intimp.2024.113089

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