Article
Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance.
Genes & development - 1 Jun 2015
Choudhury Malay, Zaman Shamsu, Jiang James C, Jazwinski S Michal, Bastia Deepak
Abstract excerpt
Protein-mediated "chromosome kissing" between two DNA sites in trans (or in cis) is known to facilitate three-dimensional control of gene expression and DNA replication. However, the mechanisms of regulation of the long-range interactions are unknown. Here, we show that the replication terminator protein Fob1 of Saccharomyces cerevisiae promoted chromosome kissing that initiated rDNA recombination and controlled...
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