Article
Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice.
Atherosclerosis - 1 Apr 2012
Ewing M M, Karper J C, Sampietro M L, de Vries M R, Pettersson K, Jukema J W, Quax P H A
Abstract excerpt
BACKGROUND: Activated cells in atherosclerotic lesions expose phosphatidylserine (PS) on their surface. Annexin A5 (AnxA5) binds to PS and is used for imaging atherosclerotic lesions. Recently, AnxA5 was shown to inhibit vascular inflammatory processes after vein grafting. Here, we report a therapeutic role for AnxA5 in post-interventional vascular remodeling in a mouse model mimicking percutaneous coronary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.