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Article

Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking.

Addiction biology - 1 Mar 2016

Suchankova Petra, Nilsson Staffan, von der Pahlen Bettina, Santtila Pekka, Sandnabba Kenneth, Johansson Ada, Jern Patrick, Engel Jörgen A, Jerlhag Elisabet

Abstract excerpt

The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consume alcohol in rodents. Moreover, ghrelin signaling is required for the rewarding properties of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26059200
DOI: 10.1111/adb.12277
PMCID: PMC5033010

Genes

GHSR
GHRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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