Article
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity.
PloS one - 9 Apr 2010
Gjesing Anette P, Larsen Lesli H, Torekov Signe S, Hainerová Irena Aldhoon, Kapur Rahul, Johansen Anders, Albrechtsen Anders, Boj Sylvia, Holst Birgitte, Harper Angela, Urhammer Søren A, Borch-Johnsen Knut, Pisinger Charlotta, Echwald Søren M, Eiberg Hans, Astrup Arne, Lebl Jan, Ferrer Jorge, Schwartz Thue W, Hansen Torben, Pedersen Oluf
Abstract excerpt
BACKGROUND: The growth hormone secretagogue receptor (GHSR) is mediating hunger sensation when stimulated by its natural ligand ghrelin. In the present study, we tested the hypothesis that common and rare variation in the GHSR locus are related to increased prevalence of obesity and overweight among Whites. METHODOLOGY/PRINCIPAL FINDINGS: In a population-based study sample of 15,854 unrelated, middle-aged Danes,...
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