Article
Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Carcinogenesis - 1 Jul 2008
Dossus Laure, McKay James D, Canzian Federico, Wilkening Stefan, Rinaldi Sabina, Biessy Carine, Olsen Anja, Tjønneland Anne, Jakobsen Marianne U, Overvad Kim, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Fournier Agnes, Linseisen Jakob, Lukanova Annekatrin, Boeing Heiner, Fisher Eva, Trichopoulou Antonia, Georgila Christina, Trichopoulos Dimitrios, Palli Domenico, Krogh Vittorio, Tumino Rosario, Vineis Paolo, Quirós José Ramon, Sala Núria, Martínez-García Carmen, Dorronsoro Miren, Chirlaque Maria-Dolores, Barricarte Aurelio, van Duijnhoven Fränzel J B, Bueno-de-Mesquita H B, van Gils Carla H, Peeters Petra H M, Hallmans Göran, Lenner Per, Bingham Sheila, Khaw Kay Tee, Key Tim J, Travis Ruth C, Ferrari Pietro, Jenab Mazda, Riboli Elio, Kaaks Rudolf
Abstract excerpt
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer...
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