Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.

Abstract excerpt

Bellini and colleagues demonstrate the importance of next-generation sequencing to uncover subclonal anaplastic lymphoma kinase (ALK) mutations in neuroblastoma. Although the significance of these subclonal aberrations is not yet understood, deep sequencing could identify patients whose tumors may respond to ALK inhibitors.

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