Article
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis.
Antioxidants & redox signaling - 1 Dec 2015
Matte Alessandro, De Falco Luigia, Iolascon Achille, Mohandas Narla, An Xiuli, Siciliano Angela, Leboeuf Christophe, Janin Anne, Bruno Mariasole, Choi Soo Young, Kim Dae Won, De Franceschi Lucia
Abstract excerpt
AIMS: β-Thalassemia is a common inherited red cell disorder characterized by ineffective erythropoiesis and severe oxidative stress. Peroxiredoxin-2 (Prx2), a typical 2-cysteine peroxiredoxin, is upregulated during β-thalassemic erythropoiesis, but its contribution to stress erythropoiesis, a common feature of thalassemia, is yet to be fully defined. RESULTS: Here, we showed that Prx2(-/-) mice displayed reactive...
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