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Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

5 Apr 2011

Abstract excerpt

Although hematopoietic stem cell transplantation and gene therapy have the potential to cure β-thalassemia and sickle cell disease, they are not currently available to most people with these diseases. In the near term, pharmacologic induction of fetal hemoglobin (HbF) may offer the best possibility for safe, effective, and widely available therapy. In an effort to define new pathways for targeted drug development...

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PMID: 21464371
DOI: 10.1182/blood-2010-10-314096

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